| Reaction Details |
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 | Report a problem with these data |
| Target | SUMO-activating enzyme subunit 1 |
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| Ligand | BDBM46589 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | uHTS HTRF assay for identification of inhibitors of SUMOylation |
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| IC50 | 3920±n/a nM |
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| Citation |  PubChem, PC uHTS HTRF assay for identification of inhibitors of SUMOylation PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| SUMO-activating enzyme subunit 1 |
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| Name: | SUMO-activating enzyme subunit 1 |
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| Synonyms: | AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38440.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_17390638 |
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| Residue: | 346 |
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| Sequence: | MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK
VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
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| BDBM46589 |
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| n/a |
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| Name | BDBM46589 |
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| Synonyms: | 2-[(1,8-diamino-5-cyano-6-piperidin-1-yl-2,7-naphthyridin-3-yl)sulfanyl]acetic acid | 2-[(1,8-diamino-5-cyano-6-piperidino-2,7-naphthyridin-3-yl)thio]acetic acid | 2-[[1,8-bis(azanyl)-5-cyano-6-piperidin-1-yl-2,7-naphthyridin-3-yl]sulfanyl]ethanoic acid | 2-[[1,8-diamino-5-cyano-6-(1-piperidinyl)-2,7-naphthyridin-3-yl]thio]acetic acid | MLS000773334 | SMR000364051 | cid_3327739 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H18N6O2S |
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| Mol. Mass. | 358.418 |
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| SMILES | Nc1nc(SCC(O)=O)cc2c(C#N)c(nc(N)c12)N1CCCCC1 |
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| Structure | 
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