Ki Summary

Reaction Details

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Target

SUMO-activating enzyme subunit 1

Ligand

BDBM53205

Substrate/Competitor

n/a

Meas. Tech.

uHTS HTRF assay for identification of inhibitors of SUMOylation

IC50

2110±n/a nM

Citation

PubChem, PC uHTS HTRF assay for identification of inhibitors of SUMOylation PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

SUMO-activating enzyme subunit 1

Name:

SUMO-activating enzyme subunit 1

Synonyms:

AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A

Type:

Enzyme Catalytic Domain

Mol. Mass.:

38440.84

Organism:

Homo sapiens (Human)

Description:

gi_17390638

Residue:

346

Sequence:

MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK
VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK

BDBM53205

n/a

Name

BDBM53205

Synonyms:

1,3-bis[[(Z)-(3-hydroxy-4-keto-cyclohexa-2,5-dien-1-ylidene)methyl]amino]urea | 1,3-bis[[(Z)-(3-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]amino]urea | 1,3-bis[[(Z)-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]amino]urea | 1,3-bis[[(Z)-(3-oxidanyl-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)methyl]amino]urea | MLS001202140 | N'',N'''-bis[(1E)-(3,4-dihydroxyphenyl)methylene]carbonohydrazide | SMR000565039 | cid_24762014

Type

Small organic molecule

Emp. Form.

C15H14N4O5

Mol. Mass.

330.2955

SMILES

O=C(NN=CC1=CC(=O)C(=O)CC1)NN=CC1=CC(=O)C(=O)CC1 |w:3.2,14.14,t:5,17|

Structure