| Reaction Details |
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 | Report a problem with these data |
| Target | SUMO-activating enzyme subunit 1 |
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| Ligand | BDBM61244 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | uHTS HTRF assay for identification of inhibitors of SUMOylation |
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| IC50 | 9170±n/a nM |
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| Citation |  PubChem, PC uHTS HTRF assay for identification of inhibitors of SUMOylation PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| SUMO-activating enzyme subunit 1 |
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| Name: | SUMO-activating enzyme subunit 1 |
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| Synonyms: | AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38440.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_17390638 |
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| Residue: | 346 |
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| Sequence: | MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK
VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
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| BDBM61244 |
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| n/a |
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| Name | BDBM61244 |
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| Synonyms: | MLS001175206 | N-[5-(diethylsulfamoyl)-2-hydroxy-phenyl]-2-(3,4,5-trimethoxyphenyl)cinchoninamide | N-[5-(diethylsulfamoyl)-2-hydroxyphenyl]-2-(3,4,5-trimethoxyphenyl)-4-quinolinecarboxamide | N-[5-(diethylsulfamoyl)-2-hydroxyphenyl]-2-(3,4,5-trimethoxyphenyl)quinoline-4-carboxamide | N-[5-(diethylsulfamoyl)-2-oxidanyl-phenyl]-2-(3,4,5-trimethoxyphenyl)quinoline-4-carboxamide | SMR000589889 | cid_4321047 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H31N3O7S |
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| Mol. Mass. | 565.637 |
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| SMILES | CCN(CC)S(=O)(=O)c1ccc(O)c(NC(=O)c2cc(nc3ccccc23)-c2cc(OC)c(OC)c(OC)c2)c1 |
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| Structure | 
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