| Reaction Details |
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 | Report a problem with these data |
| Target | SUMO-activating enzyme subunit 1 |
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| Ligand | BDBM61250 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | uHTS HTRF assay for identification of inhibitors of SUMOylation |
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| IC50 | 4160±n/a nM |
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| Citation |  PubChem, PC uHTS HTRF assay for identification of inhibitors of SUMOylation PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| SUMO-activating enzyme subunit 1 |
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| Name: | SUMO-activating enzyme subunit 1 |
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| Synonyms: | AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38440.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_17390638 |
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| Residue: | 346 |
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| Sequence: | MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK
VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
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| BDBM61250 |
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| n/a |
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| Name | BDBM61250 |
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| Synonyms: | 2-azanylidene-3-(4-bromophenyl)sulfonyl-1-(furan-2-ylmethyl)dipyrido[1,2-d:3',4'-f]pyrimidin-5-one | 3-(4-bromophenyl)sulfonyl-1-(2-furanylmethyl)-2-imino-5-dipyrido[1,2-d:3',4'-f]pyrimidinone | 3-(4-bromophenyl)sulfonyl-1-(furan-2-ylmethyl)-2-iminodipyrido[1,2-d:3',4'-f]pyrimidin-5-one | 3-brosyl-1-(2-furfuryl)-2-imino-dipyrido[1,2-d:3',4'-f]pyrimidin-5-one | MLS001146179 | SMR000646858 | cid_3321332 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H15BrN4O4S |
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| Mol. Mass. | 511.348 |
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| SMILES | Brc1ccc(cc1)S(=O)(=O)c1cc2c(nc3ccccn3c2=O)n(Cc2ccco2)c1=N |
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| Structure | 
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