| Reaction Details |
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 | Report a problem with these data |
| Target | Tumor necrosis factor |
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| Ligand | BDBM50312 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | SAR analysis of inhibitors of TNFa specific NF-kB induction revised |
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| IC50 | 230±n/a nM |
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| Citation |  PubChem, PC SAR analysis of inhibitors of TNFa specific NF-kB induction revised PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Tumor necrosis factor |
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| Name: | Tumor necrosis factor |
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| Synonyms: | Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha |
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| Type: | Enzyme |
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| Mol. Mass.: | 25645.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P01375 |
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| Residue: | 233 |
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| Sequence: | MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
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| BDBM50312 |
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| n/a |
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| Name | BDBM50312 |
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| Synonyms: | 2-[(4,6-difluoro-1,3-benzothiazol-2-yl)amino]-1,3-benzothiazole-6-carboxylic acid methyl ester | MLS000720339 | SMR000236235 | cid_7110073 | methyl 2-[(4,6-difluoro-1,3-benzothiazol-2-yl)amino]-1,3-benzothiazole-6-carboxylate | methyl 2-[[4,6-bis(fluoranyl)-1,3-benzothiazol-2-yl]amino]-1,3-benzothiazole-6-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C16H9F2N3O2S2 |
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| Mol. Mass. | 377.388 |
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| SMILES | COC(=O)c1ccc2nc(Nc3nc4c(F)cc(F)cc4s3)sc2c1 |
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| Structure | 
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