| Reaction Details |
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 | Report a problem with these data |
| Target | Tumor necrosis factor |
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| Ligand | BDBM54340 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction |
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| IC50 | 8786±1300 nM |
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| Citation |  PubChem, PC HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Tumor necrosis factor |
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| Name: | Tumor necrosis factor |
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| Synonyms: | Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha |
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| Type: | Enzyme |
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| Mol. Mass.: | 25645.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P01375 |
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| Residue: | 233 |
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| Sequence: | MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
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| BDBM54340 |
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| n/a |
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| Name | BDBM54340 |
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| Synonyms: | 4-[4-(3-chlorophenyl)-1-piperazinyl]-3-methylisoxazolo[5,4-d]pyrimidine | 4-[4-(3-chlorophenyl)piperazin-1-yl]-3-methyl-[1,2]oxazolo[5,4-d]pyrimidine | 4-[4-(3-chlorophenyl)piperazino]-3-methyl-isoxazolo[5,4-d]pyrimidine | 4-[4-(3-chlorophenyl)piperazino]-3-methylisoxazolo[5,4-d]pyrimidine | MLS000706926 | SMR000335751 | cid_1481225 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16ClN5O |
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| Mol. Mass. | 329.784 |
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| SMILES | Cc1noc2ncnc(N3CCN(CC3)c3cccc(Cl)c3)c12 |
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| Structure | 
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