Reaction Details |
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Target | Beta-lactamase |
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Ligand | BDBM60189 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase |
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IC50 | 3498±n/a nM |
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Citation | PubChem, PC Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase PubChem Bioassay(2010)[AID] |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Beta-lactamase |
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Name: | Beta-lactamase |
Synonyms: | Beta-lactamase | metallo-beta-lactamase IMP-1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 27125.88 |
Organism: | Pseudomonas aeruginosa |
Description: | gi_27368096 |
Residue: | 246 |
Sequence: | MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNA
EAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELT
NELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKP
YGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK
PSKPSN
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BDBM60189 |
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n/a |
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Name | BDBM60189 |
Synonyms: | 2-[7-(4-methyl-1-piperazinyl)-4,4a,5,6-tetrahydro-3H-naphthalen-2-ylidene]propanedinitrile | 2-[7-(4-methylpiperazin-1-yl)-4,4a,5,6-tetrahydro-3H-naphthalen-2-ylidene]propanedinitrile | 2-[7-(4-methylpiperazino)-4,4a,5,6-tetrahydro-3H-naphthalen-2-ylidene]malononitrile | MLS001007142 | SMR000352400 | cid_4406525 |
Type | Small organic molecule |
Emp. Form. | C18H22N4 |
Mol. Mass. | 294.3941 |
SMILES | [#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-[#6]-1=[#6]-[#6]-2=[#6]\[#6](-[#6]-[#6]-[#6]-2-[#6]-[#6]-1)=[#6](\C#N)C#N |t:8,10| |
Structure |
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