Ki Summary

Reaction Details

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Target

Bcl-2-like protein 11

Ligand

BDBM61070

Substrate/Competitor

n/a

Meas. Tech.

Luminescence Cell-Based Dose Retest to Identify Inhibitors of A1 Apoptosis

EC50

6176±n/a nM

Citation

PubChem, PC Luminescence Cell-Based Dose Retest to Identify Inhibitors of A1 Apoptosis PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Bcl-2-like protein 11

Name:

Bcl-2-like protein 11

Synonyms:

B2L11_HUMAN | BCL2-like 11 isoform 1 | BCL2L11 | BIM

Type:

PROTEIN

Mol. Mass.:

22175.26

Organism:

Homo sapiens (Human)

Description:

EBI_101325

Residue:

198

Sequence:

MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSP
QGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPP
CQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPR
MVILRLLRYIVRLVWRMH

BDBM61070

n/a

Name

BDBM61070

Synonyms:

(Z)-2-[3-(4-chlorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl]-3-[4-(difluoromethoxy)phenyl]-2-propenoic acid ethyl ester | (Z)-2-[3-(4-chlorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl]-3-[4-(difluoromethoxy)phenyl]acrylic acid ethyl ester | MLS000417101 | SMR000264333 | cid_6217704 | ethyl (Z)-2-[3-(4-chlorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl]-3-[4-(difluoromethoxy)phenyl]prop-2-enoate | ethyl (Z)-3-[4-[bis(fluoranyl)methoxy]phenyl]-2-[3-(4-chlorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl]prop-2-enoate

Type

Small organic molecule

Emp. Form.

C22H17ClF2N4O3S

Mol. Mass.

490.91

SMILES

CCOC(=O)C(=Cc1ccc(OC(F)F)cc1)C1=Nn2c(SC1)nnc2-c1ccc(Cl)cc1 |w:6.6,t:18|

Structure