Ki Summary

Reaction Details

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Target

Bcl-2-like protein 11

Ligand

BDBM67052

Substrate/Competitor

n/a

Meas. Tech.

Luminescence Cell-Based Dose Retest to Identify Inhibitors of A1 Apoptosis

EC50

3270±n/a nM

Citation

PubChem, PC Luminescence Cell-Based Dose Retest to Identify Inhibitors of A1 Apoptosis PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Bcl-2-like protein 11

Name:

Bcl-2-like protein 11

Synonyms:

B2L11_HUMAN | BCL2-like 11 isoform 1 | BCL2L11 | BIM

Type:

PROTEIN

Mol. Mass.:

22175.26

Organism:

Homo sapiens (Human)

Description:

EBI_101325

Residue:

198

Sequence:

MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSP
QGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPP
CQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPR
MVILRLLRYIVRLVWRMH

BDBM67052

n/a

Name

BDBM67052

Synonyms:

MLS002276354 | SMR001317989 | [(2R,3aS,3bR,5aS,9aS,9bR,11aS)-2-[(2R)-2-acetyloxy-5-oxidanylidene-2H-furan-3-yl]-3b,6,6,9a-tetramethyl-2,3,3a,4,5,5a,7,8,9,9b,10,11-dodecahydronaphtho[2,1-e][1]benzofuran-11a-yl]methyl ethanoate | [(2R,3aS,3bR,5aS,9aS,9bR,11aS)-2-[(2R)-2-acetyloxy-5-oxo-2H-furan-3-yl]-3b,6,6,9a-tetramethyl-2,3,3a,4,5,5a,7,8,9,9b,10,11-dodecahydronaphtho[2,1-e][1]benzofuran-11a-yl]methyl acetate | acetic acid [(2R,3aS,3bR,5aS,9aS,9bR,11aS)-2-[(2R)-2-acetoxy-5-keto-2H-furan-3-yl]-3b,6,6,9a-tetramethyl-2,3,3a,4,5,5a,7,8,9,9b,10,11-dodecahydronaphtho[2,1-e]benzofuran-11a-yl]methyl ester | acetic acid [(2R,3aS,3bR,5aS,9aS,9bR,11aS)-2-[(2R)-2-acetyloxy-5-oxo-2H-furan-3-yl]-3b,6,6,9a-tetramethyl-2,3,3a,4,5,5a,7,8,9,9b,10,11-dodecahydronaphtho[2,1-e]benzofuran-11a-yl]methyl ester | cid_44201401

Type

Small organic molecule

Emp. Form.

C29H42O7

Mol. Mass.

502.6396

SMILES

CC(=O)OC[C@]12CC[C@H]3[C@@](C)(CC[C@H]4C(C)(C)CCC[C@]34C)[C@@H]1C[C@@H](O2)C1=CC(=O)O[C@H]1OC(C)=O |t:30|

Structure