| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DNA damage-inducible transcript 3 protein |
|---|
| Ligand | BDBM67710 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress |
|---|
| IC50 | 9420±n/a nM |
|---|
| Citation |  PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay(2010)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| DNA damage-inducible transcript 3 protein |
|---|
| Name: | DNA damage-inducible transcript 3 protein |
|---|
| Synonyms: | Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 19175.17 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | gi_160707929 |
|---|
| Residue: | 168 |
|---|
| Sequence: | MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASL
AWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMK
EKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
|
|
|
|---|
| BDBM67710 |
|---|
| n/a |
|---|
| Name | BDBM67710 |
|---|
| Synonyms: | 7-(4-chlorobenzyl)-3-methyl-8-(sec-butylthio)xanthine | 8-(butan-2-ylthio)-7-[(4-chlorophenyl)methyl]-3-methylpurine-2,6-dione | 8-butan-2-ylsulfanyl-7-[(4-chlorophenyl)methyl]-3-methyl-purine-2,6-dione | 8-butan-2-ylsulfanyl-7-[(4-chlorophenyl)methyl]-3-methylpurine-2,6-dione | 8-sec-Butylsulfanyl-7-(4-chloro-benzyl)-3-methyl-3,7-dihydro-purine-2,6-dione | MLS000030735 | SMR000009153 | cid_654111 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H19ClN4O2S |
|---|
| Mol. Mass. | 378.876 |
|---|
| SMILES | CCC(C)Sc1nc2n(C)c(=O)[nH]c(=O)c2n1Cc1ccc(Cl)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
