Ki Summary

Reaction Details

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Target

DNA damage-inducible transcript 3 protein

Ligand

BDBM67720

Substrate/Competitor

n/a

Meas. Tech.

Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress

IC50

>10000±n/a nM

Citation

PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

DNA damage-inducible transcript 3 protein

Name:

DNA damage-inducible transcript 3 protein

Synonyms:

Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153

Type:

Enzyme Catalytic Domain

Mol. Mass.:

19175.17

Organism:

Mus musculus

Description:

gi_160707929

Residue:

168

Sequence:

MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASL
AWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMK
EKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA

BDBM67720

n/a

Name

BDBM67720

Synonyms:

(6Z)-6-[2-amino-5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-1H-pyrimidin-6-ylidene]-3-methoxy-4-propyl-1-cyclohexa-2,4-dienone | (6Z)-6-[2-amino-5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-1H-pyrimidin-6-ylidene]-3-methoxy-4-propyl-cyclohexa-2,4-dien-1-one | (6Z)-6-[2-amino-5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-1H-pyrimidin-6-ylidene]-3-methoxy-4-propylcyclohexa-2,4-dien-1-one | (6Z)-6-[2-azanyl-5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-1H-pyrimidin-6-ylidene]-3-methoxy-4-propyl-cyclohexa-2,4-dien-1-one | MLS000038398 | SMR000040425 | cid_5389129

Type

Small organic molecule

Emp. Form.

C23H25N3O4

Mol. Mass.

407.4623

SMILES

CCCc1cc(c(O)cc1OC)-c1nc(N)ncc1-c1ccc2OCCCOc2c1

Structure