| Reaction Details |
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 | Report a problem with these data |
| Target | DNA damage-inducible transcript 3 protein |
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| Ligand | BDBM67826 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress |
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| IC50 | 780±n/a nM |
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| Citation |  PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| DNA damage-inducible transcript 3 protein |
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| Name: | DNA damage-inducible transcript 3 protein |
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| Synonyms: | Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 19175.17 |
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| Organism: | Mus musculus |
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| Description: | gi_160707929 |
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| Residue: | 168 |
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| Sequence: | MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASL
AWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMK
EKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
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| BDBM67826 |
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| n/a |
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| Name | BDBM67826 |
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| Synonyms: | 2-(4-bromanylpyrazol-1-yl)-4-thiophen-2-yl-6-(trifluoromethyl)pyrimidine | 2-(4-bromo-1-pyrazolyl)-4-thiophen-2-yl-6-(trifluoromethyl)pyrimidine | 2-(4-bromopyrazol-1-yl)-4-(2-thienyl)-6-(trifluoromethyl)pyrimidine | 2-(4-bromopyrazol-1-yl)-4-thiophen-2-yl-6-(trifluoromethyl)pyrimidine | MLS000520043 | SMR000130458 | cid_3502533 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H6BrF3N4S |
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| Mol. Mass. | 375.167 |
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| SMILES | FC(F)(F)c1cc(nc(n1)-n1cc(Br)cn1)-c1cccs1 |
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| Structure | 
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