| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DNA damage-inducible transcript 3 protein |
|---|
| Ligand | BDBM66374 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress |
|---|
| IC50 | 1170±n/a nM |
|---|
| Citation |  PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay(2010)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| DNA damage-inducible transcript 3 protein |
|---|
| Name: | DNA damage-inducible transcript 3 protein |
|---|
| Synonyms: | Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 19175.17 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | gi_160707929 |
|---|
| Residue: | 168 |
|---|
| Sequence: | MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASL
AWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMK
EKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
|
|
|
|---|
| BDBM66374 |
|---|
| n/a |
|---|
| Name | BDBM66374 |
|---|
| Synonyms: | 2-[(4-chlorobenzoyl)amino]-4-methyl-valeric acid [2-keto-2-(3-keto-4H-1,4-benzoxazin-6-yl)ethyl] ester | 2-[[(4-chlorophenyl)-oxomethyl]amino]-4-methylpentanoic acid [2-oxo-2-(3-oxo-4H-1,4-benzoxazin-6-yl)ethyl] ester | MLS000571077 | SMR000150696 | [2-oxidanylidene-2-(3-oxidanylidene-4H-1,4-benzoxazin-6-yl)ethyl] 2-[(4-chlorophenyl)carbonylamino]-4-methyl-pentanoate | [2-oxo-2-(3-oxo-4H-1,4-benzoxazin-6-yl)ethyl] 2-[(4-chlorobenzoyl)amino]-4-methylpentanoate | cid_3930624 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H23ClN2O6 |
|---|
| Mol. Mass. | 458.892 |
|---|
| SMILES | CC(C)CC(NC(=O)c1ccc(Cl)cc1)C(=O)OCC(=O)c1ccc2OCC(=O)Nc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
