Ki Summary

Reaction Details

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Target

DNA damage-inducible transcript 3 protein

Ligand

BDBM52406

Substrate/Competitor

n/a

Meas. Tech.

Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress

IC50

170±n/a nM

Citation

PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

DNA damage-inducible transcript 3 protein

Name:

DNA damage-inducible transcript 3 protein

Synonyms:

Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153

Type:

Enzyme Catalytic Domain

Mol. Mass.:

19175.17

Organism:

Mus musculus

Description:

gi_160707929

Residue:

168

Sequence:

MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASL
AWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMK
EKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA

BDBM52406

n/a

Name

BDBM52406

Synonyms:

4-[(5Z)-5-(4-ethylbenzylidene)-4-keto-2-thioxo-thiazolidin-3-yl]-N-(2-pyridyl)butyramide | 4-[(5Z)-5-[(4-ethylphenyl)methylidene]-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-pyridin-2-yl-butanamide | 4-[(5Z)-5-[(4-ethylphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-pyridin-2-ylbutanamide | 4-[(5Z)-5-[(4-ethylphenyl)methylidene]-4-oxo-2-sulfanylidene-3-thiazolidinyl]-N-(2-pyridinyl)butanamide | 4-[5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-2-pyridinylbutanamide | MLS000573304 | SMR000194806 | cid_1335223

Type

Small organic molecule

Emp. Form.

C21H21N3O2S2

Mol. Mass.

411.54

SMILES

CCc1ccc(\C=C2/SC(=S)N(CCCC(=O)Nc3ccccn3)C2=O)cc1

Structure