Reaction Details | |||
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Target | DNA damage-inducible transcript 3 protein | ||
Ligand | BDBM68062 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress | ||
IC50 | <160±n/a nM | ||
Citation | PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay(2010)[AID] | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
DNA damage-inducible transcript 3 protein | |||
Name: | DNA damage-inducible transcript 3 protein | ||
Synonyms: | Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 19175.17 | ||
Organism: | Mus musculus | ||
Description: | gi_160707929 | ||
Residue: | 168 | ||
Sequence: |
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BDBM68062 | |||
n/a | |||
Name | BDBM68062 | ||
Synonyms: | MLS000335164 | N-cyclopropyl-5-[1-(2-fluorophenyl)-2,5-dimethyl-3-pyrrolyl]-6H-1,3,4-thiadiazin-2-amine | N-cyclopropyl-5-[1-(2-fluorophenyl)-2,5-dimethyl-pyrrol-3-yl]-6H-1,3,4-thiadiazin-2-amine | N-cyclopropyl-5-[1-(2-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-6H-1,3,4-thiadiazin-2-amine | SMR000249922 | cid_4543045 | cyclopropyl-[5-[1-(2-fluorophenyl)-2,5-dimethyl-pyrrol-3-yl]-6H-1,3,4-thiadiazin-2-yl]amine | ||
Type | Small organic molecule | ||
Emp. Form. | C18H19FN4S | ||
Mol. Mass. | 342.434 | ||
SMILES | Cc1cc(c(C)n1-c1ccccc1F)C1=NN=C(NC2CC2)SC1 |t:16,18,(8.87,4.61,;7.96,3.37,;8.44,1.9,;7.19,1,;5.95,1.9,;4.48,1.43,;6.42,3.37,;5.52,4.61,;3.99,4.45,;3.08,5.7,;3.71,7.11,;5.24,7.27,;6.14,6.02,;7.67,6.18,;7.19,-.54,;8.53,-1.31,;8.53,-2.85,;7.19,-3.62,;7.19,-5.16,;8.53,-5.93,;9.3,-7.27,;10.07,-5.93,;5.86,-2.85,;5.86,-1.31,)| | ||
Structure |