| Reaction Details |
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 | Report a problem with these data |
| Target | DNA damage-inducible transcript 3 protein |
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| Ligand | BDBM68077 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress |
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| IC50 | 4870±n/a nM |
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| Citation |  PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| DNA damage-inducible transcript 3 protein |
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| Name: | DNA damage-inducible transcript 3 protein |
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| Synonyms: | Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 19175.17 |
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| Organism: | Mus musculus |
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| Description: | gi_160707929 |
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| Residue: | 168 |
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| Sequence: | MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASL
AWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMK
EKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
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| BDBM68077 |
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| n/a |
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| Name | BDBM68077 |
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| Synonyms: | 2-[[3-aminocarbonyl-5-methyl-4-(4-propan-2-ylphenyl)thiophen-2-yl]carbamoyl]-7-propan-2-ylidene-bicyclo[2.2.1]heptane-3-carboxylic acid | 2-[[3-carbamoyl-5-methyl-4-(4-propan-2-ylphenyl)thiophen-2-yl]carbamoyl]-7-propan-2-ylidenebicyclo[2.2.1]heptane-3-carboxylic acid | 2-[[[3-carbamoyl-5-methyl-4-(4-propan-2-ylphenyl)-2-thiophenyl]amino]-oxomethyl]-7-propan-2-ylidene-3-bicyclo[2.2.1]heptanecarboxylic acid | 3-({[3-(aminocarbonyl)-4-(4-isopropylphenyl)-5-methyl-2-thienyl]amino}carbonyl)-7-(1-methylethylidene)bicyclo[2.2.1]heptane-2-carboxylic acid | 3-[(3-carbamoyl-5-methyl-4-p-cumenyl-2-thienyl)carbamoyl]-7-isopropylidene-norbornane-2-carboxylic acid | MLS000705540 | SMR000231305 | cid_4462756 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H32N2O4S |
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| Mol. Mass. | 480.619 |
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| SMILES | [H]C12[#6]-[#6]C([H])([#6](-[#6]1-[#6](-[#8])=O)-[#6](=O)-[#7]-c1sc(-[#6])c(c1-[#6](-[#7])=O)-c1ccc(cc1)-[#6](-[#6])-[#6])\[#6]2=[#6](\[#6])-[#6] |TLB:11:6:32:3.2,THB:8:7:32:3.2| |
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| Structure | 
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