Ki Summary

Reaction Details

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Target

DNA damage-inducible transcript 3 protein

Ligand

BDBM55675

Substrate/Competitor

n/a

Meas. Tech.

Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress

IC50

2170±n/a nM

Citation

PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

DNA damage-inducible transcript 3 protein

Name:

DNA damage-inducible transcript 3 protein

Synonyms:

Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153

Type:

Enzyme Catalytic Domain

Mol. Mass.:

19175.17

Organism:

Mus musculus

Description:

gi_160707929

Residue:

168

Sequence:

MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASL
AWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMK
EKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA

BDBM55675

n/a

Name

BDBM55675

Synonyms:

(E)-N-[2-(cyclohexylamino)-2-keto-ethyl]-N-(4-fluorobenzyl)-4-(2-hydroxy-4-methoxy-phenyl)-4-keto-but-2-enamide | (E)-N-[2-(cyclohexylamino)-2-oxidanylidene-ethyl]-N-[(4-fluorophenyl)methyl]-4-(4-methoxy-2-oxidanyl-phenyl)-4-oxidanylidene-but-2-enamide | (E)-N-[2-(cyclohexylamino)-2-oxoethyl]-N-[(4-fluorophenyl)methyl]-4-(2-hydroxy-4-methoxyphenyl)-4-oxo-2-butenamide | (E)-N-[2-(cyclohexylamino)-2-oxoethyl]-N-[(4-fluorophenyl)methyl]-4-(2-hydroxy-4-methoxyphenyl)-4-oxobut-2-enamide | MLS000714568 | SMR000274547 | cid_5770961

Type

Small organic molecule

Emp. Form.

C26H29FN2O5

Mol. Mass.

468.5173

SMILES

COc1ccc(C(=O)\C=C\C(=O)N(CC(=O)NC2CCCCC2)Cc2ccc(F)cc2)c(O)c1

Structure