| Reaction Details |
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 | Report a problem with these data |
| Target | Signal transducer and activator of transcription 1-alpha/beta |
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| Ligand | BDBM68333 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Late stage results from the probe development effort to identify activators of signal transducer and activator of transcription 1 (STAT1) |
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| EC50 | >229.17±n/a nM |
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| Citation |  PubChem, PC Late stage results from the probe development effort to identify activators of signal transducer and activator of transcription 1 (STAT1): luminescence-based cell-based dose response assay for STAT1 activators PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Signal transducer and activator of transcription 1-alpha/beta |
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| Name: | Signal transducer and activator of transcription 1-alpha/beta |
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| Synonyms: | STAT1 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor STAT1 | Transcription factor ISGF-3 components p91/p84 | signal transducer and activator of transcription 1 isoform alpha |
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| Type: | Cytosolic Transcription Factor |
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| Mol. Mass.: | 87327.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Stat1 was expressed in sf9 cells from a baculovirus encoding the recombinant proteins. Stat1 dimer binds to DNA. |
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| Residue: | 750 |
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| Sequence: | MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL
LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ
RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR
EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK
RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV
LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV
KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN
EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE
PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT
RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL
LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP
ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT
DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
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| BDBM68333 |
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| n/a |
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| Name | BDBM68333 |
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| Synonyms: | 5-methyl-3-phenyl-7-(4-pyridyl)pyrazolo[1,5-a]pyrimidine | 5-methyl-3-phenyl-7-(4-pyridyl)pyrazolo[1,5-a]pyrimidine;2,2,2-trifluoroacetic acid | 5-methyl-3-phenyl-7-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine;2,2,2-tris(fluoranyl)ethanoic acid | 5-methyl-3-phenyl-7-pyridin-4-ylpyrazolo[1,5-a]pyrimidine;2,2,2-trifluoroacetic acid | SR-03000000952-1 | cid_42640810 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14N4 |
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| Mol. Mass. | 286.3306 |
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| SMILES | Cc1cc(-c2ccncc2)n2ncc(-c3ccccc3)c2n1 |
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| Structure | 
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