Ki Summary

Reaction Details

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Target

Heat shock factor protein 1

Ligand

BDBM71661

Substrate/Competitor

n/a

Meas. Tech.

Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)

EC50

>260000±n/a nM

Citation

PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Heat shock factor protein 1

Name:

Heat shock factor protein 1

Synonyms:

HSF1_MOUSE | Hsf1 | Hsf1 protein

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57208.68

Organism:

Mus musculus

Description:

P38532

Residue:

525

Sequence:

MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY
FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT
SVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA
QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPY
SAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQE
PPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPAL
PTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTM
PDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTG
SSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS

BDBM71661

n/a

Name

BDBM71661

Synonyms:

3-[2-(2-Methylcarbamoylmethyl-benzoimidazol-1-yl)-acetylamino]-benzoic acid ethyl ester | 3-[[2-[2-[2-(methylamino)-2-oxoethyl]-1-benzimidazolyl]-1-oxoethyl]amino]benzoic acid ethyl ester | 3-[[2-[2-[2-keto-2-(methylamino)ethyl]benzimidazol-1-yl]acetyl]amino]benzoic acid ethyl ester | MLS000073857 | SMR000002627 | cid_656250 | ethyl 3-[2-[2-[2-(methylamino)-2-oxidanylidene-ethyl]benzimidazol-1-yl]ethanoylamino]benzoate | ethyl 3-[[2-[2-[2-(methylamino)-2-oxoethyl]benzimidazol-1-yl]acetyl]amino]benzoate

Type

Small organic molecule

Emp. Form.

C21H22N4O4

Mol. Mass.

394.4238

SMILES

CCOC(=O)c1cccc(NC(=O)Cn2c(CC(=O)NC)nc3ccccc23)c1

Structure