Ki Summary

Reaction Details

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Target

Heat shock factor protein 1

Ligand

BDBM71726

Substrate/Competitor

n/a

Meas. Tech.

Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)

EC50

>260000±n/a nM

Citation

PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Heat shock factor protein 1

Name:

Heat shock factor protein 1

Synonyms:

HSF1_MOUSE | Hsf1 | Hsf1 protein

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57208.68

Organism:

Mus musculus

Description:

P38532

Residue:

525

Sequence:

MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY
FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT
SVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA
QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPY
SAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQE
PPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPAL
PTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTM
PDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTG
SSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS

BDBM71726

n/a

Name

BDBM71726

Synonyms:

3-benzyl-7-ethyl-1-(4H-[1,2,4]triazolo[3,4-c][1,4]benzothiazin-1-ylmethyl)purine-2,6-dione | 3-benzyl-7-ethyl-1-(4H-[1,2,4]triazolo[3,4-c][1,4]benzothiazin-1-ylmethyl)xanthine | 7-ethyl-3-(phenylmethyl)-1-(4H-[1,2,4]triazolo[3,4-c][1,4]benzothiazin-1-ylmethyl)purine-2,6-dione | MLS000054877 | SMR000066455 | cid_2999195

Type

Small organic molecule

Emp. Form.

C24H21N7O2S

Mol. Mass.

471.534

SMILES

CCn1cnc2n(Cc3ccccc3)c(=O)n(Cc3nnc4CSc5ccccc5-n34)c(=O)c12

Structure