Ki Summary

Reaction Details

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Target

Heat shock factor protein 1

Ligand

BDBM71766

Substrate/Competitor

n/a

Meas. Tech.

Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)

EC50

63690±n/a nM

Citation

PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Heat shock factor protein 1

Name:

Heat shock factor protein 1

Synonyms:

HSF1_MOUSE | Hsf1 | Hsf1 protein

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57208.68

Organism:

Mus musculus

Description:

P38532

Residue:

525

Sequence:

MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY
FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT
SVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA
QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPY
SAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQE
PPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPAL
PTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTM
PDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTG
SSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS

BDBM71766

n/a

Name

BDBM71766

Synonyms:

4-(2-furanylmethylamino)-2-(2-methoxy-2-oxoethyl)-5-methyl-6-thieno[2,3-d]pyrimidinecarboxylic acid ethyl ester | 4-(2-furfurylamino)-2-(2-keto-2-methoxy-ethyl)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid ethyl ester | MLS000046886 | SMR000032897 | cid_3239479 | ethyl 4-(furan-2-ylmethylamino)-2-(2-methoxy-2-oxidanylidene-ethyl)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate | ethyl 4-(furan-2-ylmethylamino)-2-(2-methoxy-2-oxoethyl)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate | ethyl 4-[(2-furylmethyl)amino]-2-(2-methoxy-2-oxoethyl)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate

Type

Small organic molecule

Emp. Form.

C18H19N3O5S

Mol. Mass.

389.426

SMILES

CCOC(=O)c1sc2nc(CC(=O)OC)nc(NCc3ccco3)c2c1C

Structure