Ki Summary

Reaction Details

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Target

Heat shock factor protein 1

Ligand

BDBM71921

Substrate/Competitor

n/a

Meas. Tech.

Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)

EC50

14620±n/a nM

Citation

PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Heat shock factor protein 1

Name:

Heat shock factor protein 1

Synonyms:

HSF1_MOUSE | Hsf1 | Hsf1 protein

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57208.68

Organism:

Mus musculus

Description:

P38532

Residue:

525

Sequence:

MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY
FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT
SVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA
QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPY
SAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQE
PPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPAL
PTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTM
PDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTG
SSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS

BDBM71921

n/a

Name

BDBM71921

Synonyms:

(4E)-4-(2-keto-5-phenyl-2-pyrrolin-3-ylidene)-4-phenyl-butyric acid methyl ester | (4E)-4-(2-oxo-5-phenyl-1H-pyrrol-3-ylidene)-4-phenylbutanoic acid methyl ester | 4-[2-Oxo-5-phenyl-1,2-dihydro-pyrrol-(3E)-ylidene]-4-phenyl-butyric acid methyl ester | MLS000552432 | SMR000145947 | cid_909143 | methyl (4E)-4-(2-oxidanylidene-5-phenyl-1H-pyrrol-3-ylidene)-4-phenyl-butanoate | methyl (4E)-4-(2-oxo-5-phenyl-1H-pyrrol-3-ylidene)-4-phenylbutanoate

Type

Small organic molecule

Emp. Form.

C21H19NO3

Mol. Mass.

333.3805

SMILES

COC(=O)CC\C(=C1\C=C(NC1=O)c1ccccc1)c1ccccc1 |c:8|

Structure