Ki Summary

Reaction Details

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Target

Protein LANA1

Ligand

BDBM73513

Substrate/Competitor

n/a

Meas. Tech.

Fluorescence Polarization Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of the LANA Histone H2A/H2B Interaction

EC50

4927±n/a nM

Citation

PubChem, PC Fluorescence Polarization Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of the LANA Histone H2A/H2B Interaction PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Protein LANA1

Name:

Protein LANA1

Synonyms:

LANA | LANA1 | LANA1_HHV8P

Type:

Enzyme Catalytic Domain

Mol. Mass.:

131093.36

Organism:

Human herpesvirus 8

Description:

Q9QR71

Residue:

1129

Sequence:

MAPPGMRLRSGRSTGAPLTRGSCRKRNRSPERCDLGDDLHLQPRRKHVADSVDGRECGPH
TLPIPGSPTVFTSGLPAFVSSPTLPVAPIPSPAPATPLPPPALLPPVTTSSSPIPPSHPV
SPGTTDTHSPSPALPPTQSPESSQRPPLSSPTGRPDSSTPMRPPPSQQTTPPHSPTTPPP
EPPSKSSPDSLAPSTLRSLRKRRLSSPQGPSTLNPICQSPPVSPPRCDFANRSVYPPWAT
ESPIYVGSSSDGDTPPRQPPTSPISIGSSSPSEGSWGDDTAMLVLLAEIAEEASKNEKEC
SENNQAGEDNGDNEISKESQVDKDDNDNKDDEEEQETDEEDEEDDEEDDEEDDEEDDEED
DEEDDEEDDEEEDEEEDEEEDEEEDEEEEEDEEDDDDEDNEDEEDDEEEDKKEDEEDGGD
GNKTLSIQSSQQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQREPQQRE
PQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQQEPQQQE
PQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQDEQQQD
EQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEE
QQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEEQEQQEEQEQQE
EQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQ
ELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQEQELEEVEEQEQEQEEQE
LEEVEEQEQEQEEQEEQELEEVEEQEEQELEEVEEQEEQELEEVEEQEQQGVEQQEQETV
EEPIILHGSSSEDEMEVDYPVVSTHEQIASSPPGDNTPDDDPQPGPSREYRYVLRTSPPH
RPGVRMRRVPVTHPKKPHPRYQQPPVPYRQIDDCPAKARPQHIFYRRFLGKDGRRDPKCQ
WKFAVIFWGNDPYGLKKLSQAFQFGGVKAGPVSCLPHPGPDQSPITYCVYVYCQNKDTSK
KVQMARLAWEASHPLAGNLQSSIVKFKKPLPLTQPGENQGPGDSPQEMT

BDBM73513

n/a

Name

BDBM73513

Synonyms:

2-[4-[(2-tert-butyl-2-methyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl]phenoxy]-N-phenylacetamide | 2-[4-[(2-tert-butyl-4,6-diketo-2-methyl-1,3-dioxan-5-ylidene)methyl]phenoxy]-N-phenyl-acetamide | 2-[4-[[2-tert-butyl-2-methyl-4,6-bis(oxidanylidene)-1,3-dioxan-5-ylidene]methyl]phenoxy]-N-phenyl-ethanamide | 2-{4-[(2-tert-butyl-2-methyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl]phenoxy}-N-phenylacetamide | MLS000702700 | SMR000230245 | cid_985005

Type

Small organic molecule

Emp. Form.

C24H25NO6

Mol. Mass.

423.4584

SMILES

CC(C)(C)C1(C)OC(=O)C(=Cc2ccc(OCC(=O)Nc3ccccc3)cc2)C(=O)O1 |(15.29,8.65,;14.52,7.32,;15.85,6.55,;13.53,8.49,;13.75,5.98,;12.57,6.97,;15.08,5.21,;15.08,3.67,;16.42,2.9,;13.75,2.9,;13.75,1.36,;12.42,.59,;11.08,1.36,;9.75,.59,;9.75,-.95,;8.41,-1.72,;8.41,-3.26,;7.08,-4.03,;5.75,-3.26,;7.08,-5.57,;5.75,-6.34,;4.41,-5.57,;3.08,-6.34,;3.08,-7.88,;4.41,-8.65,;5.75,-7.88,;11.08,-1.72,;12.42,-.95,;12.42,3.67,;11.08,2.9,;12.42,5.21,)|

Structure