| Reaction Details |
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 | Report a problem with these data |
| Target | Protein LANA1 |
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| Ligand | BDBM51183 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Polarization Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of the LANA Histone H2A/H2B Interaction |
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| EC50 | 295.2±n/a nM |
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| Citation |  PubChem, PC Fluorescence Polarization Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of the LANA Histone H2A/H2B Interaction PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Protein LANA1 |
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| Name: | Protein LANA1 |
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| Synonyms: | LANA | LANA1 | LANA1_HHV8P |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 131093.36 |
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| Organism: | Human herpesvirus 8 |
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| Description: | Q9QR71 |
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| Residue: | 1129 |
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| Sequence: | MAPPGMRLRSGRSTGAPLTRGSCRKRNRSPERCDLGDDLHLQPRRKHVADSVDGRECGPH
TLPIPGSPTVFTSGLPAFVSSPTLPVAPIPSPAPATPLPPPALLPPVTTSSSPIPPSHPV
SPGTTDTHSPSPALPPTQSPESSQRPPLSSPTGRPDSSTPMRPPPSQQTTPPHSPTTPPP
EPPSKSSPDSLAPSTLRSLRKRRLSSPQGPSTLNPICQSPPVSPPRCDFANRSVYPPWAT
ESPIYVGSSSDGDTPPRQPPTSPISIGSSSPSEGSWGDDTAMLVLLAEIAEEASKNEKEC
SENNQAGEDNGDNEISKESQVDKDDNDNKDDEEEQETDEEDEEDDEEDDEEDDEEDDEED
DEEDDEEDDEEEDEEEDEEEDEEEDEEEEEDEEDDDDEDNEDEEDDEEEDKKEDEEDGGD
GNKTLSIQSSQQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQREPQQRE
PQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQQEPQQQE
PQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQDEQQQD
EQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEE
QQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEEQEQQEEQEQQE
EQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQ
ELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQEQELEEVEEQEQEQEEQE
LEEVEEQEQEQEEQEEQELEEVEEQEEQELEEVEEQEEQELEEVEEQEQQGVEQQEQETV
EEPIILHGSSSEDEMEVDYPVVSTHEQIASSPPGDNTPDDDPQPGPSREYRYVLRTSPPH
RPGVRMRRVPVTHPKKPHPRYQQPPVPYRQIDDCPAKARPQHIFYRRFLGKDGRRDPKCQ
WKFAVIFWGNDPYGLKKLSQAFQFGGVKAGPVSCLPHPGPDQSPITYCVYVYCQNKDTSK
KVQMARLAWEASHPLAGNLQSSIVKFKKPLPLTQPGENQGPGDSPQEMT
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| BDBM51183 |
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| n/a |
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| Name | BDBM51183 |
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| Synonyms: | (6Z)-5-azanylidene-3-(2-methylpropylsulfanyl)-6-[(4-oxidanylidenechromen-3-yl)methylidene]-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one | (6Z)-5-imino-3-(2-methylpropylsulfanyl)-6-[(4-oxochromen-3-yl)methylidene]-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one | (6Z)-5-imino-3-(2-methylpropylthio)-6-[(4-oxo-1-benzopyran-3-yl)methylidene]-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one | (6Z)-5-imino-3-(isobutylthio)-6-[(4-ketochromen-3-yl)methylene]-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one | (6Z)-5-imino-3-(isobutylthio)-6-[(4-oxo-4H-chromen-3-yl)methylene]-5,6-dihydro-7H-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one | MLS000731452 | SMR000309727 | cid_16193843 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H16N4O3S2 |
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| Mol. Mass. | 412.485 |
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| SMILES | CC(C)CSC1=NSC2=NC(=O)\C(=C/c3coc4ccccc4c3=O)C(=N)N12 |t:5,8| |
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| Structure | 
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