Ki Summary

Reaction Details

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Target

Protein LANA1

Ligand

BDBM46991

Substrate/Competitor

n/a

Meas. Tech.

Fluorescence Polarization Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of the LANA Histone H2A/H2B Interaction

EC50

>75000±n/a nM

Citation

PubChem, PC Fluorescence Polarization Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of the LANA Histone H2A/H2B Interaction PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Protein LANA1

Name:

Protein LANA1

Synonyms:

LANA | LANA1 | LANA1_HHV8P

Type:

Enzyme Catalytic Domain

Mol. Mass.:

131093.36

Organism:

Human herpesvirus 8

Description:

Q9QR71

Residue:

1129

Sequence:

MAPPGMRLRSGRSTGAPLTRGSCRKRNRSPERCDLGDDLHLQPRRKHVADSVDGRECGPH
TLPIPGSPTVFTSGLPAFVSSPTLPVAPIPSPAPATPLPPPALLPPVTTSSSPIPPSHPV
SPGTTDTHSPSPALPPTQSPESSQRPPLSSPTGRPDSSTPMRPPPSQQTTPPHSPTTPPP
EPPSKSSPDSLAPSTLRSLRKRRLSSPQGPSTLNPICQSPPVSPPRCDFANRSVYPPWAT
ESPIYVGSSSDGDTPPRQPPTSPISIGSSSPSEGSWGDDTAMLVLLAEIAEEASKNEKEC
SENNQAGEDNGDNEISKESQVDKDDNDNKDDEEEQETDEEDEEDDEEDDEEDDEEDDEED
DEEDDEEDDEEEDEEEDEEEDEEEDEEEEEDEEDDDDEDNEDEEDDEEEDKKEDEEDGGD
GNKTLSIQSSQQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQREPQQRE
PQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQQEPQQQE
PQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQDEQQQD
EQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEE
QQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEEQEQQEEQEQQE
EQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQ
ELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQEQELEEVEEQEQEQEEQE
LEEVEEQEQEQEEQEEQELEEVEEQEEQELEEVEEQEEQELEEVEEQEQQGVEQQEQETV
EEPIILHGSSSEDEMEVDYPVVSTHEQIASSPPGDNTPDDDPQPGPSREYRYVLRTSPPH
RPGVRMRRVPVTHPKKPHPRYQQPPVPYRQIDDCPAKARPQHIFYRRFLGKDGRRDPKCQ
WKFAVIFWGNDPYGLKKLSQAFQFGGVKAGPVSCLPHPGPDQSPITYCVYVYCQNKDTSK
KVQMARLAWEASHPLAGNLQSSIVKFKKPLPLTQPGENQGPGDSPQEMT

BDBM46991

n/a

Name

BDBM46991

Synonyms:

3-(4-chlorophenyl)-5-methyl-4-(2-tosylpyrazol-3-yl)isoxazole | 3-(4-chlorophenyl)-5-methyl-4-[2-(4-methylphenyl)sulfonyl-3-pyrazolyl]isoxazole | 3-(4-chlorophenyl)-5-methyl-4-[2-(4-methylphenyl)sulfonylpyrazol-3-yl]-1,2-oxazole | 3-(4-chlorophenyl)-5-methyl-4-{1-[(4-methylphenyl)sulfonyl]-1H-pyrazol-5-yl}isoxazole | MLS001111122 | SMR000457056 | cid_2745583

Type

Small organic molecule

Emp. Form.

C20H16ClN3O3S

Mol. Mass.

413.877

SMILES

Cc1onc(c1-c1ccnn1S(=O)(=O)c1ccc(C)cc1)-c1ccc(Cl)cc1 |(6.9,-2.18,;7.81,-.93,;9.35,-.93,;9.82,.53,;8.58,1.44,;7.33,.53,;5.87,1.01,;5.39,2.47,;3.85,2.47,;3.37,1.01,;4.62,.1,;4.62,-1.44,;6.16,-1.44,;3.08,-1.44,;4.62,-2.98,;3.29,-3.75,;3.29,-5.29,;4.62,-6.06,;4.62,-7.6,;5.95,-5.29,;5.95,-3.75,;8.58,2.98,;7.24,3.75,;7.24,5.29,;8.58,6.06,;8.58,7.6,;9.91,5.29,;9.91,3.75,)|

Structure