Ki Summary

Reaction Details

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Target

Protein LANA1

Ligand

BDBM74350

Substrate/Competitor

n/a

Meas. Tech.

Fluorescence Polarization Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of the LANA Histone H2A/H2B Interaction

EC50

1723±n/a nM

Citation

PubChem, PC Fluorescence Polarization Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of the LANA Histone H2A/H2B Interaction PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Protein LANA1

Name:

Protein LANA1

Synonyms:

LANA | LANA1 | LANA1_HHV8P

Type:

Enzyme Catalytic Domain

Mol. Mass.:

131093.36

Organism:

Human herpesvirus 8

Description:

Q9QR71

Residue:

1129

Sequence:

MAPPGMRLRSGRSTGAPLTRGSCRKRNRSPERCDLGDDLHLQPRRKHVADSVDGRECGPH
TLPIPGSPTVFTSGLPAFVSSPTLPVAPIPSPAPATPLPPPALLPPVTTSSSPIPPSHPV
SPGTTDTHSPSPALPPTQSPESSQRPPLSSPTGRPDSSTPMRPPPSQQTTPPHSPTTPPP
EPPSKSSPDSLAPSTLRSLRKRRLSSPQGPSTLNPICQSPPVSPPRCDFANRSVYPPWAT
ESPIYVGSSSDGDTPPRQPPTSPISIGSSSPSEGSWGDDTAMLVLLAEIAEEASKNEKEC
SENNQAGEDNGDNEISKESQVDKDDNDNKDDEEEQETDEEDEEDDEEDDEEDDEEDDEED
DEEDDEEDDEEEDEEEDEEEDEEEDEEEEEDEEDDDDEDNEDEEDDEEEDKKEDEEDGGD
GNKTLSIQSSQQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQREPQQRE
PQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQQEPQQQE
PQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQDEQQQD
EQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEE
QQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEEQEQQEEQEQQE
EQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQ
ELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQEQELEEVEEQEQEQEEQE
LEEVEEQEQEQEEQEEQELEEVEEQEEQELEEVEEQEEQELEEVEEQEQQGVEQQEQETV
EEPIILHGSSSEDEMEVDYPVVSTHEQIASSPPGDNTPDDDPQPGPSREYRYVLRTSPPH
RPGVRMRRVPVTHPKKPHPRYQQPPVPYRQIDDCPAKARPQHIFYRRFLGKDGRRDPKCQ
WKFAVIFWGNDPYGLKKLSQAFQFGGVKAGPVSCLPHPGPDQSPITYCVYVYCQNKDTSK
KVQMARLAWEASHPLAGNLQSSIVKFKKPLPLTQPGENQGPGDSPQEMT

BDBM74350

n/a

Name

BDBM74350

Synonyms:

MLS001360432 | SMR001223890 | [6-amino-9-(2-carbomethoxyphenyl)xanthen-3-ylidene]ammonium;chloride;hydrate | [6-amino-9-(2-methoxycarbonylphenyl)-3-xanthenylidene]ammonium;chloride;hydrate | [6-amino-9-(2-methoxycarbonylphenyl)xanthen-3-ylidene]azanium;chloride;hydrate | [6-azanyl-9-(2-methoxycarbonylphenyl)xanthen-3-ylidene]azanium;chloride;hydrate | cid_24207752

Type

Small organic molecule

Emp. Form.

C21H17N2O3

Mol. Mass.

345.3707

SMILES

COC(=O)c1ccccc1-c1c2ccc(N)cc2oc2cc(=[NH2+])ccc12 |(12.56,9.29,;13.55,8.11,;13.02,6.67,;14.01,5.49,;11.5,6.4,;11.5,7.94,;10.17,8.71,;8.84,7.94,;8.84,6.4,;10.17,5.63,;10.17,4.09,;8.84,3.32,;7.46,4.14,;6.06,3.35,;6.06,1.75,;4.73,.97,;7.46,.95,;8.84,1.78,;10.17,1.01,;11.5,1.78,;12.88,.95,;14.28,1.75,;15.61,.97,;14.28,3.35,;12.88,4.14,;11.5,3.32,)|

Structure