Ki Summary

Reaction Details

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Target

Importin subunit alpha-1

Ligand

BDBM30644

Substrate/Competitor

n/a

Meas. Tech.

Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.

EC50

9712±n/a nM

Citation

PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Importin subunit alpha-1

Name:

Importin subunit alpha-1

Synonyms:

IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57852.15

Organism:

Homo sapiens (Human)

Description:

gi_119609447

Residue:

529

Sequence:

MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF

BDBM30644

n/a

Name

BDBM30644

Synonyms:

5-ethyl-N-(4-thiazolo[5,4-b]pyridin-2-ylphenyl)thiophene-2-sulfonamide | 5-ethyl-N-[4-(2-thiazolo[5,4-b]pyridinyl)phenyl]-2-thiophenesulfonamide | 5-ethyl-N-[4-([1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl]thiophene-2-sulfonamide | MLS-0111397.0001 | cid_9550341

Type

Small organic molecule

Emp. Form.

C18H15N3O2S3

Mol. Mass.

401.526

SMILES

CCc1ccc(s1)S(=O)(=O)Nc1ccc(cc1)-c1nc2cccnc2s1

Structure