Ki Summary

Reaction Details

Report a problem with these data

Target

Importin subunit alpha-1

Ligand

BDBM59935

Substrate/Competitor

n/a

Meas. Tech.

Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.

EC50

5730±n/a nM

Citation

PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Importin subunit alpha-1

Name:

Importin subunit alpha-1

Synonyms:

IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57852.15

Organism:

Homo sapiens (Human)

Description:

gi_119609447

Residue:

529

Sequence:

MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF

BDBM59935

n/a

Name

BDBM59935

Synonyms:

(E)-2-(Morpholine-4-carbonyl)-3-(5-morpholin-4-yl-furan-2-yl)-acrylonitrile | (E)-2-(morpholine-4-carbonyl)-3-(5-morpholin-4-ylfuran-2-yl)prop-2-enenitrile | (E)-2-(morpholine-4-carbonyl)-3-(5-morpholino-2-furyl)acrylonitrile | (E)-2-morpholin-4-ylcarbonyl-3-(5-morpholin-4-ylfuran-2-yl)prop-2-enenitrile | (E)-3-[5-(4-morpholinyl)-2-furanyl]-2-[4-morpholinyl(oxo)methyl]-2-propenenitrile | MLS000589661 | SMR000219435 | cid_839237

Type

Small organic molecule

Emp. Form.

C16H19N3O4

Mol. Mass.

317.3398

SMILES

O=C(N1CCOCC1)C(=C\c1ccc(o1)N1CCOCC1)\C#N

Structure