| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Importin subunit alpha-1 |
|---|
| Ligand | BDBM75012 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. |
|---|
| EC50 | >500000±n/a nM |
|---|
| Citation |  PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Importin subunit alpha-1 |
|---|
| Name: | Importin subunit alpha-1 |
|---|
| Synonyms: | IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 57852.15 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_119609447 |
|---|
| Residue: | 529 |
|---|
| Sequence: | MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
|
|
|
|---|
| BDBM75012 |
|---|
| n/a |
|---|
| Name | BDBM75012 |
|---|
| Synonyms: | 5-[2-(2-ethyl-1-piperidinyl)-2-oxoethoxy]-2-methyl-3,4-dihydroisoquinolin-1-one | 5-[2-(2-ethylpiperidin-1-yl)-2-oxidanylidene-ethoxy]-2-methyl-3,4-dihydroisoquinolin-1-one | 5-[2-(2-ethylpiperidin-1-yl)-2-oxoethoxy]-2-methyl-3,4-dihydroisoquinolin-1-one | 5-[2-(2-ethylpiperidino)-2-keto-ethoxy]-2-methyl-3,4-dihydroisocarbostyril | MLS000685865 | SMR000323071 | cid_3638908 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H26N2O3 |
|---|
| Mol. Mass. | 330.4213 |
|---|
| SMILES | CCC1CCCCN1C(=O)COc1cccc2C(=O)N(C)CCc12 |
|---|
| Structure | 
|
|---|
Search and Browse
