| Reaction Details |
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 | Report a problem with these data |
| Target | Importin subunit alpha-1 |
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| Ligand | BDBM75025 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. |
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| EC50 | 9416±n/a nM |
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| Citation |  PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Importin subunit alpha-1 |
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| Name: | Importin subunit alpha-1 |
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| Synonyms: | IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 57852.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_119609447 |
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| Residue: | 529 |
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| Sequence: | MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
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| BDBM75025 |
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| n/a |
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| Name | BDBM75025 |
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| Synonyms: | 4-[4-(dimethylamino)phenyl]-1-methyl-2-(methylthio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | 4-[4-(dimethylamino)phenyl]-1-methyl-2-(methylthio)-6-oxo-5-pyrimidinecarbonitrile | 4-[4-(dimethylamino)phenyl]-1-methyl-2-methylsulfanyl-6-oxidanylidene-pyrimidine-5-carbonitrile | 4-[4-(dimethylamino)phenyl]-1-methyl-2-methylsulfanyl-6-oxopyrimidine-5-carbonitrile | 4-[4-(dimethylamino)phenyl]-6-keto-1-methyl-2-(methylthio)pyrimidine-5-carbonitrile | MLS000766800 | SMR000339696 | cid_694212 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H16N4OS |
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| Mol. Mass. | 300.379 |
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| SMILES | CSc1nc(-c2ccc(cc2)N(C)C)c(C#N)c(=O)n1C |
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| Structure | 
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