Ki Summary

Reaction Details

Report a problem with these data

Target

Importin subunit alpha-1

Ligand

BDBM75075

Substrate/Competitor

n/a

Meas. Tech.

Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.

EC50

54210±n/a nM

Citation

PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Importin subunit alpha-1

Name:

Importin subunit alpha-1

Synonyms:

IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57852.15

Organism:

Homo sapiens (Human)

Description:

gi_119609447

Residue:

529

Sequence:

MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF

BDBM75075

n/a

Name

BDBM75075

Synonyms:

MLS001004634 | N'-(1,3-dimethyl-2,4-dioxo-6-pteridinyl)-4-nitrobenzohydrazide | N'-(1,3-dimethyl-2,4-dioxopteridin-6-yl)-4-nitrobenzohydrazide | N'-(2,4-diketo-1,3-dimethyl-pteridin-6-yl)-4-nitro-benzohydrazide | N'-[1,3-dimethyl-2,4-bis(oxidanylidene)pteridin-6-yl]-4-nitro-benzohydrazide | SMR000348226 | cid_4199276

Type

Small organic molecule

Emp. Form.

C15H13N7O5

Mol. Mass.

371.3076

SMILES

Cn1c2ncc(NNC(=O)c3ccc(cc3)[N+]([O-])=O)nc2c(=O)n(C)c1=O

Structure