| Reaction Details |
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 | Report a problem with these data |
| Target | Importin subunit alpha-1 |
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| Ligand | BDBM36913 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. |
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| EC50 | 183100±n/a nM |
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| Citation |  PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Importin subunit alpha-1 |
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| Name: | Importin subunit alpha-1 |
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| Synonyms: | IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 57852.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_119609447 |
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| Residue: | 529 |
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| Sequence: | MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
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| BDBM36913 |
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| n/a |
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| Name | BDBM36913 |
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| Synonyms: | 2-[(2,5-dimethyl-1-pyridin-2-yl-pyrrol-3-yl)methylidene]-[1,3]thiazolo[3,2-a]benzimidazol-1-one | 2-[(2,5-dimethyl-1-pyridin-2-ylpyrrol-3-yl)methylidene]-[1,3]thiazolo[3,2-a]benzimidazol-1-one | 2-[[2,5-dimethyl-1-(2-pyridinyl)-3-pyrrolyl]methylidene]-1-thiazolo[3,2-a]benzimidazolone | 2-[[2,5-dimethyl-1-(2-pyridyl)pyrrol-3-yl]methylene]thiazolo[3,2-a]benzimidazol-1-one | MLS000036977 | SMR000036002 | cid_661826 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H16N4OS |
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| Mol. Mass. | 372.443 |
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| SMILES | Cc1cc(C=c2sc3nc4ccccc4n3c2=O)c(C)n1-c1ccccn1 |
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| Structure | 
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