Ki Summary

Reaction Details

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Target

Importin subunit alpha-1

Ligand

BDBM75076

Substrate/Competitor

n/a

Meas. Tech.

Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.

EC50

>500000±n/a nM

Citation

PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Importin subunit alpha-1

Name:

Importin subunit alpha-1

Synonyms:

IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57852.15

Organism:

Homo sapiens (Human)

Description:

gi_119609447

Residue:

529

Sequence:

MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF

BDBM75076

n/a

Name

BDBM75076

Synonyms:

2-(3-pyridyl)-N-(2-thiazolin-2-yl)cinchoninamide;hydrochloride | MLS001005547 | N-(4,5-dihydro-1,3-thiazol-2-yl)-2-pyridin-3-yl-quinoline-4-carboxamide;hydrochloride | N-(4,5-dihydro-1,3-thiazol-2-yl)-2-pyridin-3-ylquinoline-4-carboxamide;hydrochloride | N-(4,5-dihydrothiazol-2-yl)-2-(3-pyridinyl)-4-quinolinecarboxamide;hydrochloride | SMR000348857 | cid_16196953

Type

Small organic molecule

Emp. Form.

C18H14N4OS

Mol. Mass.

334.395

SMILES

O=C(NC1=NCCS1)c1cc(nc2ccccc12)-c1cccnc1 |t:3|

Structure