Ki Summary

Reaction Details

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Target

Importin subunit alpha-1

Ligand

BDBM52775

Substrate/Competitor

n/a

Meas. Tech.

Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.

EC50

77360±n/a nM

Citation

PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Importin subunit alpha-1

Name:

Importin subunit alpha-1

Synonyms:

IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57852.15

Organism:

Homo sapiens (Human)

Description:

gi_119609447

Residue:

529

Sequence:

MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF

BDBM52775

n/a

Name

BDBM52775

Synonyms:

3-Imino-1,5,7-trimethyl-2,6-dioxa-bicyclo[2.2.2]octane-4,8,8-tricarbonitrile | 3-azanylidene-1,5,7-trimethyl-2,6-dioxabicyclo[2.2.2]octane-4,8,8-tricarbonitrile | 3-imino-1,5,7-trimethyl-2,6-dioxabicyclo[2.2.2]octane-4,8,8-tricarbonitrile | MLS001029868 | SMR000426793 | cid_387801

Type

Small organic molecule

Emp. Form.

C12H12N4O2

Mol. Mass.

244.2493

SMILES

CC1OC2(C)OC(=N)C1(C#N)C(C#N)(C#N)C2C |TLB:7:6:16.11:2.1,0:1:16.11:5.6,THB:17:16:2.1:5.6|

Structure