| Reaction Details |
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 | Report a problem with these data |
| Target | Importin subunit alpha-1 |
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| Ligand | BDBM63780 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. |
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| EC50 | >500000±n/a nM |
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| Citation |  PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Importin subunit alpha-1 |
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| Name: | Importin subunit alpha-1 |
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| Synonyms: | IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 57852.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_119609447 |
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| Residue: | 529 |
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| Sequence: | MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
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| BDBM63780 |
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| n/a |
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| Name | BDBM63780 |
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| Synonyms: | 3-[4-(trifluoromethyl)phenyl]-N-[[2-(trifluoromethyl)phenyl]methyl]-4,5-dihydro-1,2-oxazole-5-carboxamide | 3-[4-(trifluoromethyl)phenyl]-N-[[2-(trifluoromethyl)phenyl]methyl]-4,5-dihydroisoxazole-5-carboxamide | MLS000561186 | N-[2-(trifluoromethyl)benzyl]-3-[4-(trifluoromethyl)phenyl]-2-isoxazoline-5-carboxamide | SMR000390830 | cid_16681990 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H14F6N2O2 |
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| Mol. Mass. | 416.3171 |
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| SMILES | FC(F)(F)c1ccc(cc1)C1=NOC(C1)C(=O)NCc1ccccc1C(F)(F)F |t:11| |
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| Structure | 
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