Ki Summary

Reaction Details

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Target

Importin subunit alpha-1

Ligand

BDBM75080

Substrate/Competitor

n/a

Meas. Tech.

Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.

EC50

12450±n/a nM

Citation

PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Importin subunit alpha-1

Name:

Importin subunit alpha-1

Synonyms:

IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57852.15

Organism:

Homo sapiens (Human)

Description:

gi_119609447

Residue:

529

Sequence:

MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF

BDBM75080

n/a

Name

BDBM75080

Synonyms:

(Z)-4-(4-cyanophenyl)-2-keto-3-(2-quinolyl)but-3-enoic acid | (Z)-4-(4-cyanophenyl)-2-oxidanylidene-3-quinolin-2-yl-but-3-enoic acid | (Z)-4-(4-cyanophenyl)-2-oxo-3-(2-quinolinyl)-3-butenoic acid | (Z)-4-(4-cyanophenyl)-2-oxo-3-quinolin-2-ylbut-3-enoic acid | MLS001033775 | SMR000385650 | cid_6043656

Type

Small organic molecule

Emp. Form.

C20H12N2O3

Mol. Mass.

328.3209

SMILES

OC(=O)C(=O)C(=C/c1ccc(cc1)C#N)\c1ccc2ccccc2n1

Structure