| Reaction Details |
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 | Report a problem with these data |
| Target | Importin subunit alpha-1 |
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| Ligand | BDBM75082 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. |
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| EC50 | >260000±n/a nM |
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| Citation |  PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Importin subunit alpha-1 |
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| Name: | Importin subunit alpha-1 |
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| Synonyms: | IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 57852.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_119609447 |
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| Residue: | 529 |
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| Sequence: | MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
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| BDBM75082 |
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| n/a |
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| Name | BDBM75082 |
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| Synonyms: | 2-[[(E)-(6-keto-4-methyl-cyclohexa-2,4-dien-1-ylidene)methyl]amino]-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester | 2-{[1-(2-Hydroxy-4-methyl-phenyl)-meth-(E)-ylidene]-amino}-6-methyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyr idine-3-carboxylic acid ethyl ester | 6-methyl-2-[[(E)-(4-methyl-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester | MLS000777153 | SMR000413549 | cid_6347707 | ethyl 6-methyl-2-[[(E)-(4-methyl-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene)methyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate | ethyl 6-methyl-2-[[(E)-(4-methyl-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22N2O3S |
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| Mol. Mass. | 358.455 |
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| SMILES | CCOC(=O)c1c2CCN(C)Cc2sc1N=Cc1ccc(C)cc1O |w:15.16| |
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| Structure | 
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