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TargetImportin subunit alpha-1
LigandBDBM75089
Substrate/Competitorn/a
Meas. Tech.Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50>500000±n/a nM
Citation PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Importin subunit alpha-1
Name:Importin subunit alpha-1
Synonyms:IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:Enzyme Catalytic Domain
Mol. Mass.:57852.15
Organism:Homo sapiens (Human)
Description:gi_119609447
Residue:529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM75089
n/a
NameBDBM75089
Synonyms:MLS000780334 | N-[4-[[(E)-N'-(4,6-dimethylpyrimidin-2-yl)amidino]amino]phenyl]propionamide | N-[4-[[(E)-N'-(4,6-dimethylpyrimidin-2-yl)carbamimidoyl]amino]phenyl]propanamide | N-[4-[[(E)-amino-[(4,6-dimethyl-2-pyrimidinyl)imino]methyl]amino]phenyl]propanamide | N-{4-[N'-(4,6-Dimethyl-pyrimidin-2-yl)-guanidino]-phenyl}-propionamide | SMR000420517 | cid_9600790
TypeSmall organic molecule
Emp. Form.C16H20N6O
Mol. Mass.312.3696
SMILESCCC(=O)Nc1ccc(cc1)N=C(N)Nc1nc(C)cc(C)n1 |w:11.11|
Structure
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