| Reaction Details |
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 | Report a problem with these data |
| Target | Importin subunit alpha-1 |
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| Ligand | BDBM75091 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. |
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| EC50 | >500000±n/a nM |
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| Citation |  PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Importin subunit alpha-1 |
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| Name: | Importin subunit alpha-1 |
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| Synonyms: | IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 57852.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_119609447 |
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| Residue: | 529 |
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| Sequence: | MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
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| BDBM75091 |
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| n/a |
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| Name | BDBM75091 |
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| Synonyms: | (5E)-5-[(1-azepanylamino)methylidene]-1-(3,4-dimethylphenyl)-1,3-diazinane-2,4,6-trione | (5E)-5-[(azepan-1-ylamino)methylene]-1-(3,4-dimethylphenyl)barbituric acid | (5E)-5-[(azepan-1-ylamino)methylidene]-1-(3,4-dimethylphenyl)-1,3-diazinane-2,4,6-trione | 5-[1-(Azepan-1-ylamino)-meth-(E)-ylidene]-1-(3,4-dimethyl-phenyl)-pyrimidine-2,4,6-trione | MLS000776013 | SMR000439975 | cid_5619250 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H24N4O3 |
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| Mol. Mass. | 356.4189 |
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| SMILES | Cc1ccc(cc1C)-n1c(O)c(C=NN2CCCCCC2)c(=O)[nH]c1=O |w:13.14| |
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| Structure | 
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