| Reaction Details |
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 | Report a problem with these data |
| Target | Importin subunit alpha-1 |
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| Ligand | BDBM52844 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. |
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| EC50 | >500000±n/a nM |
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| Citation |  PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Importin subunit alpha-1 |
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| Name: | Importin subunit alpha-1 |
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| Synonyms: | IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 57852.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_119609447 |
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| Residue: | 529 |
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| Sequence: | MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
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| BDBM52844 |
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| n/a |
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| Name | BDBM52844 |
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| Synonyms: | 4-[(5,6-dioxo-3-pyridinyl)hydrazo]benzenesulfonamide | 4-[2-(5,6-dioxopyridin-3-yl)hydrazinyl]benzenesulfonamide | 4-[2-[5,6-bis(oxidanylidene)pyridin-3-yl]hydrazinyl]benzenesulfonamide | 4-[N'-(5,6-diketo-3-pyridyl)hydrazino]benzenesulfonamide | MLS000738238 | SMR000528590 | cid_5382140 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H10N4O4S |
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| Mol. Mass. | 294.287 |
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| SMILES | NS(=O)(=O)c1ccc(cc1)N=Nc1c[nH]c(=O)c(O)c1 |w:10.10| |
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| Structure | 
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