| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Importin subunit alpha-1 |
|---|
| Ligand | BDBM50693 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. |
|---|
| EC50 | >500000±n/a nM |
|---|
| Citation |  PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Importin subunit alpha-1 |
|---|
| Name: | Importin subunit alpha-1 |
|---|
| Synonyms: | IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 57852.15 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_119609447 |
|---|
| Residue: | 529 |
|---|
| Sequence: | MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
|
|
|
|---|
| BDBM50693 |
|---|
| n/a |
|---|
| Name | BDBM50693 |
|---|
| Synonyms: | (5Z)-2-(4-fluoroanilino)-5-(1H-indol-3-ylmethylene)-2-thiazolin-4-one | (5Z)-2-(4-fluoroanilino)-5-(1H-indol-3-ylmethylidene)-1,3-thiazol-4-one | (5Z)-2-(4-fluoroanilino)-5-(1H-indol-3-ylmethylidene)-4-thiazolone | (5Z)-2-[(4-fluorophenyl)amino]-5-(1H-indol-3-ylmethylidene)-1,3-thiazol-4-one | 2-[(E)-4-Fluoro-phenylimino]-5-[1-(1H-indol-3-yl)-meth-(Z)-ylidene]-thiazolidin-4-one | MLS000806941 | SMR000414737 | cid_5530129 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H12FN3OS |
|---|
| Mol. Mass. | 337.371 |
|---|
| SMILES | Fc1ccc(NC2=NC(=O)C(S2)=Cc2c[nH]c3ccccc23)cc1 |w:12.13,t:6| |
|---|
| Structure | 
|
|---|
Search and Browse
