Reaction Details |
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Target | G-protein coupled receptor 35 |
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Ligand | BDBM61652 |
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Substrate/Competitor | n/a |
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Meas. Tech. | SAR Analysis for the identification of Selective Antagonists of ERK1/2 Activity in GPR35-Overexpressing U2OS Cells |
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IC50 | 2665±147 nM |
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Citation | PubChem, PC SAR Analysis for the identification of Selective Antagonists of ERK1/2 Activity in GPR35-Overexpressing U2OS Cells PubChem Bioassay(2010)[AID] |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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G-protein coupled receptor 35 |
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Name: | G-protein coupled receptor 35 |
Synonyms: | G protein-coupled receptor 35 | GPR35 | GPR35_HUMAN |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 34085.57 |
Organism: | Homo sapiens (Human) |
Description: | gi_33695097 |
Residue: | 309 |
Sequence: | MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMT
NLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRH
PLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGF
YLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVR
LAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKS
QDSLCVTLA
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BDBM61652 |
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n/a |
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Name | BDBM61652 |
Synonyms: | 2-hydroxy-4-[[1-oxo-4-[(5Z)-4-oxo-5-(phenylmethylene)-2-sulfanylidene-3-thiazolidinyl]butyl]amino]benzoic acid | 2-oxidanyl-4-[4-[(5Z)-4-oxidanylidene-5-(phenylmethylidene)-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoylamino]benzoic acid | 4-[4-[(5Z)-5-benzal-4-keto-2-thioxo-thiazolidin-3-yl]butanoylamino]-2-hydroxy-benzoic acid | 4-[4-[(5Z)-5-benzylidene-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoylamino]-2-hydroxybenzoic acid | MLS001157852 | SMR000651252 | cid_6226024 |
Type | Small organic molecule |
Emp. Form. | C21H18N2O5S2 |
Mol. Mass. | 442.508 |
SMILES | OC(=O)c1ccc(NC(=O)CCCN2C(=S)S\C(=C/c3ccccc3)C2=O)cc1O |
Structure |
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