Ki Summary

Reaction Details

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Target

Alkaline phosphatase, tissue-nonspecific isozyme

Ligand

BDBM43816

Substrate/Competitor

n/a

Meas. Tech.

Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase.

EC50

454±n/a nM

Citation

PubChem, PC Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase. PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Alkaline phosphatase, tissue-nonspecific isozyme

Name:

Alkaline phosphatase, tissue-nonspecific isozyme

Synonyms:

ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor

Type:

PROTEIN

Mol. Mass.:

57306.17

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1448917

Residue:

524

Sequence:

MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF

BDBM43816

n/a

Name

BDBM43816

Synonyms:

5'-bromanylspiro[1,2-dihydro-4,1,2-benzoxadiazine-3,3'-1H-indole]-2'-one | 5'-bromo-2'-spiro[1,2-dihydro-4,1,2-benzoxadiazine-3,3'-1H-indole]one | 5'-bromospiro[1,2-dihydro-4,1,2-benzoxadiazine-3,3'-1H-indole]-2'-one | 5'-bromospiro[1,2-dihydro-4,1,2-benzoxadiazine-3,3'-indoline]-2'-one | MLS-0258268.0001 | cid_4879298

Type

Small organic molecule

Emp. Form.

C14H10BrN3O2

Mol. Mass.

332.152

SMILES

Brc1ccc2NC(=O)C3(NNc4ccccc4O3)c2c1

Structure