| Reaction Details |
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 | Report a problem with these data |
| Target | Epidermal growth factor receptor [L858R] |
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| Ligand | BDBM50391089 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TBD |
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| IC50 | 2.02±n/a nM |
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| Citation |  Hu, S; Liu, X; Bai, J; Long, W Protein tyrosine kinase modulators and methods of use US Patent US10059688 Publication Date 8/28/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Epidermal growth factor receptor [L858R] |
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| Name: | Epidermal growth factor receptor [L858R] |
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| Synonyms: | EGFR | EGFR (L858R) | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR)(L858R) | Epidermal growth factor receptor (L858R) | Epidermal growth factor receptor(L858R) | HER1 |
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| Type: | n/a |
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| Mol. Mass.: | 134323.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00533[L858R] |
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| Residue: | 1210 |
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| Sequence: | MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ
QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED
SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN
TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV
APQSSEFIGA
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| BDBM50391089 |
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| n/a |
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| Name | BDBM50391089 |
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| Synonyms: | BPI-2009 | CHEMBL2087361 | Conmana | Icotinib | Lcotinib | US9783524, Icotinib |
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| Type | Small organic molecule |
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| Emp. Form. | C22H21N3O4 |
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| Mol. Mass. | 391.4198 |
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| SMILES | C#Cc1cccc(Nc2ncnc3cc4OCCOCCOCCOc4cc23)c1 |
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| Structure | 
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