Reaction Details |
| Report a problem with these data |
Target | Gag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C] |
---|
Ligand | BDBM2720 |
---|
Substrate/Competitor | (rC)n.(dG)12-18 |
---|
Meas. Tech. | HIV-1 RT Assay |
---|
pH | 7.8±n/a |
---|
Temperature | 310.15±n/a K |
---|
IC50 | 10100±n/a nM |
---|
Citation | Hogberg, M; Sahlberg, C; Engelhardt, P; Noreen, R; Kangasmetsa, J; Johansson, NG; Oberg, B; Vrang, L; Zhang, H; Sahlberg, BL; Unge, T; Lovgren, S; Fridborg, K; Backbro, K Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues. J Med Chem42:4150-60 (1999) [PubMed] Article |
---|
More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
---|
|
Gag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C] |
---|
Name: | Gag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C] |
Synonyms: | EC: 2.7.7.49 | HIV-1 Reverse Transcriptase Mutant (Y181C) |
Type: | Protein Complex |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Gag-Pol polyprotein [588-1147,Y768C] |
Synonyms: | HIV-1 Reverse Transcriptase Mutant (Y181C) Chain A | POL_HV1H2 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 64426.38 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[588-1147,Y768C] |
Residue: | 560 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVL
|
|
|
Component 2 |
Name: | Gag-Pol polyprotein [588-1127,Y768C] |
Synonyms: | HIV-1 Reverse Transcriptase Mutant (Y181C) Chain B | POL_HV1H2 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 51277.10 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[588-1127,Y768C] |
Residue: | 440 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETF
|
|
|
BDBM2720 |
---|
(rC)n.(dG)12-18 |
---|
Name: | (rC)n.(dG)12-18 |
Synonyms: | n/a |
Type: | RNA-DNA duplex |
Mol. Mass.: | 358.43 |
Organism: | n/a |
Description: | The incorporation of Tritium-labeled dGTP onto a poly(rC):oligo(dG)template:primer.
|
Residue: | 3 |
Sequence: | |