| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-adrenergic receptor kinase 1 |
|---|
| Ligand | BDBM48373 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Dose Response of inhibitors of GRK2 binding with RNA aptamer, Cherry Pick 1 |
|---|
| EC50 | 22080±n/a nM |
|---|
| Citation |  PubChem, PC Dose Response of inhibitors of GRK2 binding with RNA aptamer, Cherry Pick 1 PubChem Bioassay(2011)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Beta-adrenergic receptor kinase 1 |
|---|
| Name: | Beta-adrenergic receptor kinase 1 |
|---|
| Synonyms: | ADRBK1 | ARBK1_HUMAN | BARK | BARK1 | Beta-ARK-1 | Beta-adrenergic receptor kinase 1 | G-protein coupled receptor kinase 2 | G-protein coupled receptor kinase 2 (GRK2) | GRK2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 79581.30 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P25098 |
|---|
| Residue: | 689 |
|---|
| Sequence: | MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS
QKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLAC
SHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV
ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE
IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE
VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE
LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA
DAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARK
KAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSL
LTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQR
VPKMKNKPRSPVVELSKVPLVQRGSANGL
|
|
|
|---|
| BDBM48373 |
|---|
| n/a |
|---|
| Name | BDBM48373 |
|---|
| Synonyms: | MLS000081944 | N-(2-furanylmethyl)-2-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)thio]acetamide | N-(2-furfuryl)-2-[(4-keto-6-methyl-1H-pyrimidin-2-yl)thio]acetamide | N-(furan-2-ylmethyl)-2-[(6-methyl-4-oxidanylidene-1H-pyrimidin-2-yl)sulfanyl]ethanamide | N-(furan-2-ylmethyl)-2-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide | SMR000061049 | cid_586221 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H13N3O3S |
|---|
| Mol. Mass. | 279.315 |
|---|
| SMILES | Cc1cc(=O)[nH]c(SCC(=O)NCc2ccco2)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
