| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-adrenergic receptor kinase 1 |
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| Ligand | BDBM53267 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose Response of inhibitors of GRK2 binding with RNA aptamer, Cherry Pick 1 |
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| EC50 | 33040±n/a nM |
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| Citation |  PubChem, PC Dose Response of inhibitors of GRK2 binding with RNA aptamer, Cherry Pick 1 PubChem Bioassay(2011)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Beta-adrenergic receptor kinase 1 |
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| Name: | Beta-adrenergic receptor kinase 1 |
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| Synonyms: | ADRBK1 | ARBK1_HUMAN | BARK | BARK1 | Beta-ARK-1 | Beta-adrenergic receptor kinase 1 | G-protein coupled receptor kinase 2 | G-protein coupled receptor kinase 2 (GRK2) | GRK2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 79581.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25098 |
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| Residue: | 689 |
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| Sequence: | MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS
QKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLAC
SHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV
ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE
IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE
VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE
LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA
DAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARK
KAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSL
LTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQR
VPKMKNKPRSPVVELSKVPLVQRGSANGL
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| BDBM53267 |
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| n/a |
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| Name | BDBM53267 |
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| Synonyms: | 4-[2-[(E)-[2,4-bis(oxidanylidene)-3-(2-oxidanylidene-2-pyrrolidin-1-yl-ethyl)-1,3-thiazolidin-5-ylidene]methyl]pyrrol-1-yl]benzoic acid | 4-[2-[(E)-[2,4-diketo-3-(2-keto-2-pyrrolidino-ethyl)thiazolidin-5-ylidene]methyl]pyrrol-1-yl]benzoic acid | 4-[2-[(E)-[2,4-dioxo-3-(2-oxo-2-pyrrolidin-1-ylethyl)-1,3-thiazolidin-5-ylidene]methyl]pyrrol-1-yl]benzoic acid | 4-[2-[(E)-[2,4-dioxo-3-[2-oxo-2-(1-pyrrolidinyl)ethyl]-5-thiazolidinylidene]methyl]-1-pyrrolyl]benzoic acid | 4-{2-[2,4-Dioxo-3-(2-oxo-2-pyrrolidin-1-yl-ethyl)-thiazolidin-(5E)-ylidenemethyl]-pyrrol-1-yl}-benzoic acid | MLS001219090 | SMR000605630 | cid_6490291 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19N3O5S |
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| Mol. Mass. | 425.458 |
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| SMILES | OC(=O)c1ccc(cc1)-n1cccc1\C=C1\SC(=O)N(CC(=O)N2CCCC2)C1=O |
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| Structure | 
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