Reaction Details |
| Report a problem with these data |
Target | Protein Mdm4 |
---|
Ligand | BDBM79083 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction in luminescent format |
---|
IC50 | 9380±n/a nM |
---|
Citation | PubChem, PC Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction in luminescent format PubChem Bioassay(2011)[AID] |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Protein Mdm4 |
---|
Name: | Protein Mdm4 |
Synonyms: | Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4 |
Type: | Oncoprotein |
Mol. Mass.: | 54842.04 |
Organism: | Homo sapiens (Human) |
Description: | The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose. |
Residue: | 490 |
Sequence: | MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI
MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL
ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ
DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWF
LNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTS
EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP
DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ
RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE
IQLVIKVFIA
|
|
|
BDBM79083 |
---|
n/a |
---|
Name | BDBM79083 |
Synonyms: | 2-[2-(4-methoxyphenyl)-7-methyl-4-oxidanylidene-pyrazolo[1,5-d][1,2,4]triazin-5-yl]-N-[3-(4-piperidin-1-ylpiperidin-1-yl)propyl]ethanamide | 2-[2-(4-methoxyphenyl)-7-methyl-4-oxo-5-pyrazolo[1,5-d][1,2,4]triazinyl]-N-[3-[4-(1-piperidinyl)-1-piperidinyl]propyl]acetamide | 2-[2-(4-methoxyphenyl)-7-methyl-4-oxopyrazolo[1,5-d][1,2,4]triazin-5-yl]-N-[3-(4-piperidin-1-ylpiperidin-1-yl)propyl]acetamide | 2-[4-keto-2-(4-methoxyphenyl)-7-methyl-pyrazolo[1,5-d][1,2,4]triazin-5-yl]-N-[3-(4-piperidinopiperidino)propyl]acetamide | MLS001121252 | SMR000631236 | cid_20953769 |
Type | Small organic molecule |
Emp. Form. | C28H39N7O3 |
Mol. Mass. | 521.6544 |
SMILES | COc1ccc(cc1)-c1cc2n(n1)c(C)nn(CC(=O)NCCCN1CCC(CC1)N1CCCCC1)c2=O |
Structure |
|