| Reaction Details |
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 | Report a problem with these data |
| Target | Egl nine homolog 1 |
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| Ligand | BDBM141738 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HIF-PH Assay |
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| pH | 7.4±n/a |
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| IC50 | 800±n/a nM |
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| Comments | extracted |
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| Citation |  Ng, D; Arend, MP; Flippin, LA Naphthyridine derivatives as inhibitors of Hypoxia inducible factor (HIF) hydroxylase US Patent US9695170 Publication Date 7/4/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Egl nine homolog 1 |
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| Name: | Egl nine homolog 1 |
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| Synonyms: | C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2) |
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| Type: | Protein |
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| Mol. Mass.: | 46035.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9GZT9 |
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| Residue: | 426 |
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| Sequence: | MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQG
SEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADP
AAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLR
PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQL
VSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMV
ACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKF
DRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDS
VGKDVF
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| BDBM141738 |
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| n/a |
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| Name | BDBM141738 |
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| Synonyms: | US8921389, 197 | US9695170 197 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22N4O4 |
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| Mol. Mass. | 394.4238 |
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| SMILES | CC(=O)NCCCNC(=O)c1ncc2c(ccn(Cc3ccccc3)c2=O)c1O |
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| Structure | 
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