Ki Summary

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Target

DNA dC->dU-editing enzyme APOBEC-3A

Ligand

BDBM61300

Substrate/Competitor

n/a

Meas. Tech.

Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay

Temperature

298.15±n/a K

IC50

3040±n/a nM

Comments

extracted

Citation

PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

DNA dC->dU-editing enzyme APOBEC-3A

Name:

DNA dC->dU-editing enzyme APOBEC-3A

Synonyms:

ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A

Type:

Enzyme Catalytic Domain

Mol. Mass.:

23013.77

Organism:

Homo sapiens (Human)

Description:

gi_21955158

Residue:

199

Sequence:

MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAK
NLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHV
RLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLD
EHSQALSGRLRAILQNQGN

BDBM61300

n/a

Name

BDBM61300

Synonyms:

2-(1-adamantyl)-N-[(1-methyl-3-pyridin-1-iumyl)methylideneamino]acetamide;iodide | 2-(1-adamantyl)-N-[(1-methylpyridin-1-ium-3-yl)methyleneamino]acetamide;iodide | 2-(1-adamantyl)-N-[(1-methylpyridin-1-ium-3-yl)methylideneamino]acetamide;iodide | 2-(1-adamantyl)-N-[(1-methylpyridin-1-ium-3-yl)methylideneamino]ethanamide;iodide | MLS001013417 | SMR000353409 | cid_16196258

Type

Small organic molecule

Emp. Form.

C19H26N3O

Mol. Mass.

312.4287

SMILES

[H]C12CC3([H])CC([H])(C1)CC(CC(=O)NN=Cc1ccc[n+](C)c1)(C2)C3 |w:15.15,TLB:8:1:25:6.9.5,8:6:25:1.24.2,THB:5:6:24:3.25.2|

Structure